Progressive Multifocal Leukoencephalopathy in an AIDS Patient

Progressive multifocal leukoencephalopathy in an AIDS patient.

Progressive multifocal leukoencephalopathy (PML) is a demyelinating brain disease caused by Jamestown Canyon virus (JCV). This disease is an important cause of morbidity and mortality in acquired immunodeficiency syndrome (AIDS) patients. We report a 34-year-old man infected with HIV-1 who presented with frequent general tonic clonic seizure and left side weakness for 2 months. Clinical feature...

Progressive Multifocal Leukoencephalopathy in an Immunocompetent Patient?

A 69-year old man presents with a subacute history of worsening confusion, anxiety and abnormal gait. Brain MRI revealed an extensive non-enhancing signal abnormality of parieto-occipito-temporal white matter. CSF PCR was positive for JC virus, suggestive of progressive multifocal leukoencephalopathy (PML). Extensive workup for occult immunosuppression was negative. Although PML in an immunocom...

Progressive multifocal leukoencephalopathy in an immunocompetent patient

Progressive multifocal leukoencephalopathy in an immunocompetent patient Nicolien M. van der Kolk, Peer Arts, Ingeborg W. M. van Uden, Alexander Hoischen, Frank L. van de Veerdonk, Mihai G. Netea & Brigit A. de Jong Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands Department of Genetics, Radboud University Medical Center, Nijmegen, The Netherlands Department...

Progressive multifocal leukoencephalopathy in non-HIV patient

Progressive multifocal leukoencephalopathy in an immunocompetent patient: A case report

Progressive multifocal leukoencephalopathy (PML) is a progressive lethal demyelinating disease of the brain, caused by JC virus. Reactivation of JC virus due to reduction of cellular immunity especially in setting of AIDS, is the commonest underlying cause. PML has classically been described in individuals with profound cellular immunosuppression such as patients with AIDS, haematological malig...